mHealth low carbohydrate dietary intervention ameliorates glycaemic profile, blood pressure and weight status in people with type 2 diabetes

Kolivas, Despina; Fraser, Liz; Schweitzer, Ronald; Brukner, Peter; Moschonis, George

doi:10.1038/s44324-025-00053-6

mHealth low carbohydrate dietary intervention ameliorates glycaemic profile, blood pressure and weight status in people with type 2 diabetes

journal contribution

posted on 2025-05-05, 08:06 authored by Despina KolivasDespina Kolivas, Liz Fraser, Ronald Schweitzer, Peter BruknerPeter Brukner, George MoschonisGeorge Moschonis

Abstract: Low carbohydrate diets (LCD) have shown efficacy in managing clinical outcomes in type 2 diabetes (T2D). Incorporating digital tools into health care provides an adjunct treatment modality, to educate patients and provide clinical support. This study examines the effect of a mobile health (mHealth) LCD application (app) on glycaemic profile, blood pressure and weight status, in people with T2D. The study is an online single-arm, pre-post study that recruited people with T2D from around Australia, referred via registered supporting general practitioners (GPs). The intervention (Defeat Diabetes app) provides education and resources on the use of a LCD for ongoing management of T2D. After 3 months, our cohort of 99 participants (mean age 59 ± 11 years, 55 females) showed reduced dietary carbohydrate intake as a proportion of overall energy (−14%kJ/day, 95% CI: −17 to −11). Improvement in the primary outcome HbA1c (−1.0%, 95% CI: −1.3 to −0.7), was associated with reduction in dietary carbohydrate intake. Systolic blood pressure (SBP) improved (−6 mmHg, 95% CI: −10 to −1), while 21 participants reduced their diabetes medication dose with two participants discontinuing all diabetes medication. These findings demonstrate that people with T2D receiving LCD education and resources through the Defeat Diabetes app for 3 months improved their glycaemic profile and SBP despite decreased overall medication usage in almost one third of the study sample prescribed medication at baseline.

History

Publication Date

2025-04-08

Journal

npj Metabolic Health and Disease

Volume

3

Issue

1

Article Number

12

Pagination

10p. (p. 1-10)

Publisher

Springer Nature

ISSN

2948-2828

Rights Statement

© 2025, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.