Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H; Simpson, Richard; Ji, H; Aikawa, E; Altevogt, P; Askenase, P; Bond, VC; Borràs, FE; Breakefield, X; Budnik, V; Buzas, E; Camussi, G; Clayton, A; Cocucci, E; Falcon-Perez, JM; Gabrielsson, S; Gho, YS; Gupta, D; Harsha, HC; Hendrix, A; Hill, Andrew; Inal, JM; Jenster, G; Krämer-Albers, EM; Lim, SK; Llorente, A; Lötvall, J; Marcilla, A; Mincheva-Nilsson, L; Nazarenko, I; Nieuwland, R; Hoen, ENM Nolte-'t; Pandey, A; Patel, T; Piper, MG; Pluchino, S; Prasad, TSK; Rajendran, L; Raposo, G; Record, M; Reid, GE; Sánchez-Madrid, F; Schiffelers, RM; Siljander, P; Stensballe, A; Stoorvogel, W; Taylor, D; Thery, C; Valadi, H; van Balkom, BWM; Vázquez, J; Vidal, M; Wauben, MHM; Yáñez-Mó, M; Zoeller, M; Mathivanan, Suresh

doi:10.26181/19491692.v1

21202_Kalra,H_2012.pdf (410.08 kB)

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

journal contribution

posted on 2022-03-31, 22:39 authored by H Kalra, Richard SimpsonRichard Simpson, H Ji, E Aikawa, P Altevogt, P Askenase, VC Bond, FE Borràs, X Breakefield, V Budnik, E Buzas, G Camussi, A Clayton, E Cocucci, JM Falcon-Perez, S Gabrielsson, YS Gho, D Gupta, HC Harsha, A Hendrix, Andrew HillAndrew Hill, JM Inal, G Jenster, EM Krämer-Albers, SK Lim, A Llorente, J Lötvall, A Marcilla, L Mincheva-Nilsson, I Nazarenko, R Nieuwland, ENM Nolte-'t Hoen, A Pandey, T Patel, MG Piper, S Pluchino, TSK Prasad, L Rajendran, G Raposo, M Record, GE Reid, F Sánchez-Madrid, RM Schiffelers, P Siljander, A Stensballe, W Stoorvogel, D Taylor, C Thery, H Valadi, BWM van Balkom, J Vázquez, M Vidal, MHM Wauben, M Yáñez-Mó, M Zoeller, Suresh MathivananSuresh Mathivanan

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.

Funding

This work was supported by a NH&MRC fellowship (1016599) and LIMS fellowship to SM. Part of tool development for data upload into Vesiclepedia was funded by the eResearch Office at La Trobe University with programming support from the Victorian eResearch Strategic Initiative (VeRSI). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

History

Publication Date

2012-12-01

Journal

PLoS Biology

Volume

10

Issue

12

Article Number

e1001450

Pagination

5p.

Publisher

Public Library of Science (PLoS)

ISSN

1544-9173

Rights Statement

© 2012 Kalra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.