The sport of axe throwing has gained popularity. Axe throwing is defined as a striking sport in which competitors are required to throw an axe with accuracy and appropriate velocity. However, evidence on the role of the trunk center of mass (CoM) in axe throwing, based on in-the-field experimental settings, is lacking. The aim of this study was to understand the variation in the magnitude of trunk CoM acceleration between male and female axe throwers and its relationship to throwing accuracy. The sample consisted of 10 adult axe throwers (five males: 35.9 ± 7.5 years; five females: 25.2 ± 3.2 years) of varying skill level and experience. The axe throwers completed five single-handed overarm axe throws using their right hand. The accuracy of the axe throws was recorded, along with CoM acceleration. The overall magnitudes of trunk CoM acceleration were significantly different between the male and female axe throwers (male CoM acceleration vector: 3.6 ± 1.1; female CoM acceleration vector: 2.2 ± 0.4; p = 0.001), with males recording a higher level of accuracy (males: 76%; females: 36%) in the axe throwing task combined with greater magnitudes of vertical acceleration. Female kinematics of the trunk were observed to have significantly higher magnitudes of mediolateral acceleration (3.55 ± 1.78, p = 0.016). The overall results identified that the vector magnitude of trunk CoM acceleration was significantly correlated (r = 0.87) to performance accuracy in the male throwers. It is suggested that axe throwers should consider using trunk CoM acceleration as a viable performance metric.