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Theoretical insights into the antiradical activity and copper-catalysed oxidative damage of mexidol in the physiological environment

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journal contribution
posted on 20.05.2022, 04:38 authored by NT Hoa, M Van Bay, Adam MechlerAdam Mechler, Quan Van VoQuan Van Vo
Mexidol (MD, 2-ethyl-6-methyl-3-hydroxypyridine) is a registered therapeutic agent for the treatment of anxiety disorders. The chemical structure suggests that MD may also act as an antioxidant. In this study, the hydroperoxyl radical scavenging activity of MD was studied to establish baseline antioxidant activity, followed by an investigation of the effect of MD on the copper-catalysed oxidative damage in biological systems, using computational methods. It was found that MD exhibits moderate radical scavenging activity against HOO • in water and pentyl ethanoate solvents following the single electron transfer and formal hydrogen transfer mechanisms, respectively. MD can chelate Cu(II), forming complexes that are much harder to reduce than free Cu(II): MD chelation completely quenches the Cu(II) reduction by ascorbic acid and suppresses the rate of reduction reaction by O2⋅ - that are the main reductants of Cu(II) in biological environments. Therefore, MD exerts its anti-HO • activity primarily as an OIL-1 inhibitor.

Funding

This research is funded by the Vietnamese Ministry of Education and Training under project no. B2021-DNA-16.

History

Publication Date

01/01/2022

Journal

Royal Society Open Science

Volume

9

Issue

1

Article Number

ARTN 211239

Pagination

9p.

Publisher

The Royal Society

ISSN

2054-5703

Rights Statement

© 2022 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.