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The relationship between lifestyle and serum neurofilament light protein in Huntington’s disease

journal contribution
posted on 01.12.2020, 22:39 by T Cruickshank, D Bartlett, Andrew Govus, A Hannan, WP Teo, S Mason, J Lo, M Ziman
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. Objectives: Serum neurofilament light protein (NfL) is a promising marker of disease onset and progression in Huntington's disease (HD). This study investigated associations between lifestyle factors and NfL levels in HD mutation carriers compared to healthy age- and sex-matched controls. Materials and Methods: Participants included 29 HD mutation carriers and 15 healthy controls. Associations between serum NfL concentrations and lifestyle factors, including cardiorespiratory fitness, social network size and diversity, physical activity, cognitive reserve, smoking status, and alcohol consumption, were examined using a stepwise multivariable linear regression model. Results: Higher NfL levels were associated with lower cognitive reserve, social network size and diversity and cardiorespiratory fitness in HD mutation carriers. Group × lifestyle factor effects were observed between lower serum NfL levels and a greater social network diversity. Conclusion: These findings highlight a relationship between lifestyle factors and NfL levels in HD mutations carriers; however, longitudinal studies are required to confirm if these observed relationships persist over time.

History

Publication Date

01/05/2020

Journal

Brain and Behavior

Volume

10

Issue

5

Article Number

e01578

Pagination

7p.

Publisher

Wiley-Blackwell

ISSN

2162-3279

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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