journal contribution
posted on 2025-10-31, 04:05 authored by Dhanasekaran Sakthivel, Sarah Preston, Robin B Gasser, Tatiana Soares-da-Costa, Julia N Hernandez, Adam Shahine, MD Shakif-Azam, Peter Lock, Jamie Rossjohn, Jorge Francisco González, Matthew Perugini, Els Meeusen, David Piedrafita, Travis BeddoeTravis Beddoe Galectins are a family of glycan-binding molecules with a characteristic affinity for ß-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites.<p></p>
Funding
DS acknowledges support from the Department of State Development, Business and Innovation (DSDBI), Victoria, Australia and Australia-India Institute (AII). DS acknowledges the financial support from the Australian Society for Parasitology to attend CCP4 crystallography workshop. R.B.G.’s research was funded through grants from the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia, Yourgene Bioscience Taiwan, and Melbourne Water Corporation.
History
Publication Date
2020-08-21Journal
Communications BiologyVolume
3Article Number
464Pagination
8p.Publisher
Springer NatureISSN
2399-3642Rights Statement
© The Author(s) 2020
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