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The methylome of vertebrate sex chromosomes

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journal contribution
posted on 11.02.2022, 05:46 authored by SA Waters, A Capraro, KL McIntyre, Jennifer GravesJennifer Graves, PD Waters
DNA methylation is a key epigenetic modification in vertebrate genomes known to be involved in the regulation of gene expression, X chromosome inactivation, genomic imprinting, chromatin structure, and control of transposable elements. DNA methylation is common to all eukaryote genomes, but we still lack a complete understanding of the variation in DNA methylation patterns on sex chromosomes and between the sexes in diverse species. To better understand sex chromosome DNA methylation patterns between different amniote vertebrates, we review literature that has analyzed the genome-wide distribution of DNA methylation in mammals and birds. In each system, we focus on DNA methylation patterns on the autosomes versus the sex chromosomes.

Funding

Supported by an Australian Research Council Discovery Project DP180100931.

History

Publication Date

01/01/2018

Journal

Genes

Volume

9

Issue

5

Article Number

230

Pagination

13p. (p. 1-13)

Publisher

MDPI

ISSN

2073-4425

Rights Statement

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs.