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The many faces of CD4+ T cells: Immunological and structural characteristics

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posted on 11.02.2021, 05:28 by Demetra SM Chatzileontiadou, Stephanie Gras, Hannah Sloane, Andrea T Nguyen, Emma J Grant
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. As a major arm of the cellular immune response, CD4+ T cells are important in the control and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral role in the development and activation of B cells and CD8+ T cells. CD4+ T cells are incredibly heterogeneous, and can be divided into six main lineages based on distinct profiles, namely T helper 1, 2, 17 and 22 (Th1, Th2, Th17, Th22), regulatory T cells (Treg) and T follicular helper cells (Tfh). Recent advances in structural biology have allowed for a detailed characterisation of the molecular mechanisms that drive CD4+ T cell recognition. In this review, we discuss the defining features of the main human CD4+ T cell lineages and their role in immunity, as well as their structural characteristics underlying their detection of pathogens.

Funding

This work was supported by the Australian National Health and Medical Research Council (NHMRC). H.S. is supported by an Australian Government Research Training Program Scholarship, S.G. is supported by an NHMRC Senior Research fellowship (#1159272) and E.J.G. is supported by an NHMRC ECF fellowship (#1110429).

History

Publication Date

01/01/2021

Journal

International Journal of Molecular Sciences

Volume

22

Issue

1

Article Number

73

Pagination

27p.

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

ISSN

1422-0067

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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