The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

Henningsen, K; Mika, A; Alcock, Rebekah; Gaskell, Stephanie; Parr, A; Rauch, C; Russo, I; Snipe, RMJ; Costa, RJS

doi:10.26181/25602291.v1

The increase in core body temperature in response to exertional-heat stress can predict exercise-induced gastrointestinal syndrome

journal contribution

posted on 2024-04-15, 01:11 authored by K Henningsen, A Mika, Rebekah Alcock, Stephanie Gaskell, A Parr, C Rauch, I Russo, RMJ Snipe, RJS Costa

Utilizing metadata from existing exertional and exertional-heat stress studies, the study aimed to determine if the exercise-associated increase in core body temperature can predict the change in exercise-induced gastrointestinal syndrome (EIGS) biomarkers and exercise-associated gastrointestinal symptoms (Ex-GIS). Endurance-trained individuals completed 2 h of running exercise in temperate (21.2-30.0°C) to hot (35.0-37.2°C) ambient conditions (n = 132 trials). Blood samples were collected pre- and post-exercise to determine the change in gastrointestinal integrity biomarkers and systemic inflammatory cytokines. Physiological and thermoregulatory strain variables were assessed every 10–15 min during exercise. The strength of the linear relationship between maximal (M-Tre) and change (Δ Tre) in rectal temperature and EIGS variables was determined via Spearman’s rank correlation coefficients. While the strength of prediction was determined via simple and multiple linear regression analyses dependent on screened EIGS and Ex-GIS confounding factors. Significant positive correlations between Tre maximum (M-Tre) and change (Δ Tre) with I-FABP (rs = 0.434, p < 0.001; and rs = 0.305, p < 0.001; respectively), sCD14 (rs = 0.358, p < 0.001; and rs = 0.362, p < 0.001), systemic inflammatory response profile (SIR-Profile) (p < 0.001), and total Ex-GIS (p < 0.05) were observed. M-Tre and Δ Tre significantly predicted (adjusted R2) magnitude of change in I-FABP (R2(2,123)=0.164, p < 0.001; and R2(2,119)=0.058, p = 0.011; respectively), sCD14 (R2(2,81)=0.249, p < 0.001; and R2(2,77)=0.214, p < 0.001), SIR-Profile (p < 0.001), and total Ex-GIS (p < 0.05). Strong to weak correlations were observed between M-Tre and Δ Tre with plasma concentrations of I-FABP, sCD14, SIR-Profile, and Ex-GIS in response to exercise. M-Tre and Δ Tre can predict the magnitude of these EIGS variables and Ex-GIS in response to exercise.

Funding

The work was supported by the Faculty of Medicine, Nursing and Health Sciences, Monash University [Strategic Grant Scheme]; Entrinsic Biosciences [Research Service Agreement]; Lion Drinks and Dairy [GRIP Food and Dairy]; Sports Medicine Australia Research Foundation [Postgraduate research fund].

History

Publication Date

2024-01-01

Journal

Temperature

Volume

11

Issue

1

Pagination

20p. (p. 72-91)

Publisher

Taylor & Francis

ISSN

2332-8940

Rights Statement

© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.