The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni
journal contributionposted on 2021-12-08, 23:24 authored by Warwick GrantWarwick Grant, SR Doyle, Kirsty McCann
Wellcome Open Research is an Open Research platform. This publication is: version 2; peer review: 3 approved.We present a genome assembly and annotation of an individual female Cercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although in draft form (N50 = 99 kbp, N50[n] = 232), is largely complete based on universally conserved orthologs (BUSCOs; genome = 94.9%, protein = 96.5%) and relative to other related filarial species. These data represent the first genomic resources for the genus Cercopithifilaria, a group of parasites with a broad host range, and form the basis for comparative analysis with the human-infective parasite, Onchocerca volvulus, both of which are responsible for similar eye and skin pathologies in their respective hosts.