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The future of extracellular vesicles as Theranostics–an ISEV meeting report

journal contribution
posted on 04.12.2020, 00:54 by C Soekmadji, B Li, Y Huang, H Wang, T An, C Liu, W Pan, J Chen, Lesley SimLesley Sim, JM Falcon-Perez, YS Gho, HB Holthofer, MTN Le, A Marcilla, L O’Driscoll, F Shekari, TL Shen, AC Torrecilhas, X Yan, F Yang, H Yin, Y Xiao, Z Zhao, X Zou, Q Wang, L Zheng
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”. Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies.

Funding

This work was supported by the US Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Idea Development Award [W81XWH-16-1-0736] to CS; National Natural Science Foundation of China [81702100] to BL; National Natural Science Foundation of China [21825702] to HY; Beijing Outstanding Young Scientist program Grand [BJJWZYJH01201910003013] to HY; Major Program of Health Care and Innovation of Guangzhou Project [201604020015] to QW; National Natural Science Foundation of China [81842007] to LZ; Major Program of Health Care and Innovation of Guangzhou Project [201704020213] to LZ; Basic and Applied Basic Research Programs of Guangdong Province [2019B1515120074] to LZ. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the US Department of Defense.

History

Publication Date

01/01/2020

Journal

Journal of Extracellular Vesicles

Volume

9

Issue

1

Pagination

14p. (p. 1-14)

Publisher

Taylor & Francis

ISSN

2001-3078

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.