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The future of extracellular vesicles as Theranostics–an ISEV meeting report

journal contribution
posted on 2020-12-04, 00:54 authored by C Soekmadji, B Li, Y Huang, H Wang, T An, C Liu, W Pan, J Chen, Lesley SimLesley Sim, JM Falcon-Perez, YS Gho, HB Holthofer, MTN Le, A Marcilla, L O’Driscoll, F Shekari, TL Shen, AC Torrecilhas, X Yan, F Yang, H Yin, Y Xiao, Z Zhao, X Zou, Q Wang, L Zheng
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”. Here, we report the conclusions of roundtable discussions on the current advancement in the analysis technologies and we provide some guidelines to researchers in the field to consider the use of EVs in clinical application. The main challenges and the requirements for EV separation and characterization strategies, quality control and clinical investigation were discussed to promote the application of EVs in future clinical studies.


This work was supported by the US Department of Defense Congressionally Directed Medical Research Program Prostate Cancer Research Program Idea Development Award [W81XWH-16-1-0736] to CS; National Natural Science Foundation of China [81702100] to BL; National Natural Science Foundation of China [21825702] to HY; Beijing Outstanding Young Scientist program Grand [BJJWZYJH01201910003013] to HY; Major Program of Health Care and Innovation of Guangzhou Project [201604020015] to QW; National Natural Science Foundation of China [81842007] to LZ; Major Program of Health Care and Innovation of Guangzhou Project [201704020213] to LZ; Basic and Applied Basic Research Programs of Guangdong Province [2019B1515120074] to LZ. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the US Department of Defense.


Publication Date



Journal of Extracellular Vesicles






14p. (p. 1-14)


Taylor & Francis



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