La Trobe
nutrients-13-00172-v2.pdf (880.01 kB)
Download file

The association between diet and hepatocellular carcinoma: A systematic review

Download (880.01 kB)
journal contribution
posted on 30.03.2021, 00:55 by Elena GeorgeElena George, S Sood, A Broughton, G Cogan, M Hickey, WS Chan, S Sudan, AJ Nicoll
© 2021 by the authors. Li-censee MDPI, Basel, Switzerland. Globally, liver cancer is the sixth most common cause of cancer mortality, with hepatocel-lular carcinoma (HCC) being the most common type of primary liver cancer. Emerging evidence states that diet is recognised as a potential lifestyle-related risk factor for the development of HCC. The aim of this systematic review is to determine whether there is an association between diet and the development of HCC. Using the PRISMA guidelines, three databases (MEDLINE Complete, CINAHL and Embase) were systematically searched, and studies published until July 2020 were included. Thirty observational studies were selected. The protocol was registered with PROSPERO (CRD42019135240). Higher adherence to the Mediterranean dietary pattern, Alternative Healthy Eating Index-2010, the Urban Prudent Dietary Pattern, the Traditional Cantonese Dietary Pattern, intake of vegetables, wholegrains, fish, poultry, coffee, macronutrients such as monounsaturated fats and micronutrients such as vitamin E, vitamin B9, β-carotene, manganese and potassium were associated with a reduced risk of HCC. The results suggest a potential role of diet in the development of HCC. Further quantitative research needs to be undertaken within a range of populations to investigate diet and the relationship with HCC risk.


Publication Date








Article Number

ARTN 172


(p. 1-23)





Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.