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The anti-inflammatory drug aspirin does not protect against chemotherapy-induced memory impairment by paclitaxel in mice

journal contribution
posted on 19.01.2021, 23:40 by A Chang, NC Chung, Adam Lawther, AI Ziegler, DM Shackleford, EK Sloan, AK Walker
© Copyright © 2020 Chang, Chung, Lawther, Ziegler, Shackleford, Sloan and Walker. Inflammation has been proposed to play a causal role in chemobrain which—if true—would represent an opportunity to repurpose existing anti-inflammatory drugs for the prevention and treatment of chemobrain. Here, we show that the chemoagent paclitaxel induces memory impairment and anhedonia in mice within 24 h of treatment cessation, but inflammation is not present until 2 weeks after treatment. We find no evidence of brain inflammation as measured by cytokine analysis at any time point. Furthermore, treating with aspirin to block inflammation did not affect paclitaxel-induced memory impairment. These findings suggest that inflammation may not be responsible for memory impairment induced by paclitaxel. These results contrast with recent findings of a causal role for inflammation in cancer-induced memory deficits in mice that were prevented by treatment with oral aspirin, suggesting that cognitive impairment in cancer patients undergoing treatment may arise from multiple convergent mechanisms.

History

Publication Date

14/12/2020

Journal

Frontiers in Oncology

Volume

10

Article Number

564965

Pagination

12p. (p. 1-12)

Publisher

Frontiers Media

ISSN

2234-943X

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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