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The Concise Guide to Pharmacology 2021/22: Introduction and Other Protein Targets

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posted on 28.09.2021, 01:37 by Stephen Ph Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, Katelin E Ahlers-Dannen, Mohammed Alqinyah, Thiruma ArumugamThiruma Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P Choudhuri, Kirk M Druey, Rory A Fisher, Kyle J Gerber, John R Hepler, Shelley B Hooks, Havish S Kantheti, Behirda Karaj, Somayeh Layeghi-Ghalehsoukhteh, Jae-Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D Mascarenhas, Harrison McNabb, Carolina Montañez-Miranda, Osita Ogujiofor, Hoa Phan, David L Roman, Vincent Shaw, Benita Sjogren, Christopher SobeyChristopher Sobey, Mackenzie M Spicer, Katherine E Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri
The Concise Guide to Pharmacology 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15537. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

History

Publication Date

01/10/2021

Journal

British Journal of Pharmacology

Volume

178

Issue

S1

Pagination

26p. (p. S1-S26)

Publisher

Wiley

ISSN

1476-5381

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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