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The Concise Guide to Pharmacology 2021/22: Introduction and Other Protein Targets

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posted on 2021-09-28, 01:37 authored by Stephen Ph Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, O Peter Buneman, John A Cidlowski, Arthur Christopoulos, Anthony P Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jamie A Davies, Katelin E Ahlers-Dannen, Mohammed Alqinyah, Thiruma ArumugamThiruma Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P Choudhuri, Kirk M Druey, Rory A Fisher, Kyle J Gerber, John R Hepler, Shelley B Hooks, Havish S Kantheti, Behirda Karaj, Somayeh Layeghi-Ghalehsoukhteh, Jae-Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D Mascarenhas, Harrison McNabb, Carolina Montañez-Miranda, Osita Ogujiofor, Hoa Phan, David L Roman, Vincent Shaw, Benita Sjogren, Christopher SobeyChristopher Sobey, Mackenzie M Spicer, Katherine E Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri
The Concise Guide to Pharmacology 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (, which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.


Publication Date



British Journal of Pharmacology






26p. (p. S1-S26)





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