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The Australian dingo is an early offshoot of modern breed dogs.

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posted on 06.05.2022, 00:55 authored by Matt A Field, Sonu Yadav, Olga Dudchenko, Meera Esvaran, Benjamin D Rosen, Ksenia Skvortsova, Richard J Edwards, Jens Keilwagen, Blake J Cochran, Bikash Manandhar, Sonia Bustamante, Jacob Agerbo Rasmussen, Richard G Melvin, Barry Chernoff, Arina Omer, Zane Colaric, Eva KF Chan, Andre E Minoche, Timothy PL Smith, M Thomas P Gilbert, Ozren Bogdanovic, Robert A Zammit, Torsten Thomas, Erez L Aiden, John BallardJohn Ballard
Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

History

Publication Date

22/04/2022

Journal

Sci Adv

Volume

8

Issue

16

Pagination

15p.

Publisher

American Association for the Advancement of Science (AAAS)

ISSN

2375-2548

Rights Statement

Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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