LL was supported by the University of Cambridge MRC DTP (MR/S502443/1). JG was supported by a La Trobe University Postgraduate Research Scholarship jointly funded by the Baker Heart and Diabetes Institute and a La Trobe University Full-Fee Research Scholarship. This work was supported by core funding to MI from the: UK Medical Research Council (MR/L003120/1), British Heart Foundation (RG/13/13/30194;RG/18/13/33946), NIHR Cambridge Biomedical Research Centre (BRC-1215-20014) and Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation and Wellcome. MI was supported by the Munz Chair of Cardiovascular Prediction and Prevention. This study was supported by the Victorian Government's Operational Infrastructure Support (OIS) program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
JournalPLoS Computational Biology
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.