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Taxonomic signatures of cause-specific mortality risk in human gut microbiome

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journal contribution
posted on 13.07.2021, 08:23 by A Salosensaari, V Laitinen, AS Havulinna, G Meric, S Cheng, M Perola, L Valsta, G Alfthan, Michael Inouye, JD Watrous, T Long, RA Salido, K Sanders, C Brennan, GC Humphrey, JG Sanders, M Jain, P Jousilahti, V Salomaa, R Knight, L Lahti, T Niiranen
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

Funding

We thank all participants of the FINRISK 2002 survey for their contributions to this work, and Tara Schwartz for assistance with laboratory work, and Kari Koponen for assistance with the Healthy Food Choices index. This research was supported in part by grants from the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, the Paavo Nurmi Foundation, the Urmas Pekkala Foundation, the Finnish Medical Foundation, the Academy of Finland (295741, 307127 to L.L., V.L.; 321351 to T.N.; 321356 to A.S.H.), UTUGS graduate school (to V.L.) and the National Institutes of Health (R01ES027595 to M.J., K01DK116917 to J.D.W., R01HL134168, R01HL131532, R01HL143227 and R01HL142983 to S.C.). Additional support was provided by Illumina Inc. and Janssen Pharmaceutica through their sponsorship of the Center for Microbiome Innovation at UCSD.

History

Publication Date

11/05/2021

Journal

Nature Communications

Volume

12

Issue

1

Article Number

2671

Pagination

8p.

Publisher

Nature Communications

ISSN

2041-1723

Rights Statement

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