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Superspreading events in the transmission dynamics of SARS-CoV-2: opportunities for interventions and control

journal contribution
posted on 06.12.2020, 22:41 by BM Althouse, EA Wenger, Joel MillerJoel Miller, SV Scarpino, A Allard, L Hebert-Dufresne, H Hu
© 2020 Althouse et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the Coronavirus Disease 2019 (COVID-19) disease, has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number, which has been widely used appropriately and less appropriately to characterize the transmissibility of the virus, hides the fact that transmission is stochastic, often dominated by a small number of individuals, and heavily influenced by superspreading events (SSEs). The distinct transmission features of SARS-CoV-2, e.g., high stochasticity under low prevalence (as compared to other pathogens, such as influenza), and the central role played by SSEs on transmission dynamics cannot be overlooked. Many explosive SSEs have occurred in indoor settings, stoking the pandemic and shaping its spread, such as long-Term care facilities, prisons, meat-packing plants, produce processing facilities, fish factories, cruise ships, family gatherings, parties, and nightclubs. These SSEs demonstrate the urgent need to understand routes of transmission, while posing an opportunity to effectively contain outbreaks with targeted interventions to eliminate SSEs. Here, we describe the different types of SSEs, how they influence transmission, empirical evidence for their role in the COVID-19 pandemic, and give recommendations for control of SARS-CoV-2.

Funding

B.M.A. and E.A.W. are supported by Bill and Melinda Gates through the Global Good Fund. J.C.M. is supported by startup funding from La Trobe University. S.V.S. is supported by startup funds provided by Northeastern University. A.A. acknowledges financial support from the Sentinelle Nord initiative of the Canada First Research Excellence Fund and from the Natural Sciences and Engineering Research Council of Canada (project 2019-05183). L.H.-D. acknowledges support from the National Institutes of Health 1P20 GM125498- 01 Centers of Biomedical Research Excellence Award.

History

School

  • School of Engineering and Mathematical Sciences

Publication Date

12/11/2020

Journal

PLoS Biology

Volume

18

Issue

11

Article Number

e3000897

Pagination

13p. (p. 1-13)

Publisher

Public Library of Science

ISSN

1545-7885

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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