La Trobe
90184_Brady,R_2016.pdf (1.75 MB)

Sodium selenate treatment mitigates reduction of bone volume following traumatic brain injury in rats

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posted on 2023-02-02, 00:22 authored by RD Brady, Brian GrillsBrian Grills, Tania StasisTania Stasis, JD Wark, TJ O'Brien, SR Shultz, Stuart McDonaldStuart McDonald
Objectives: Administration of sodium selenate to rats given traumatic brain injury (TBI) attenuates brain damage and improves long-term behavioural outcomes. We have previously provided evidence that TBI causes bone loss in rats, however the effect of sodium selenate treatment on bone quantity following TBI is unknown. Methods: Rats were randomly assigned into sham injury or fluid percussion injury (FPI) groups and administered saline or sodium selenate for 12 weeks post-injury. Femora were analysed using histomorphometry, peripheral quantitative computed tomography (pQCT) and biomechanical testing. Results: Distal metaphyseal trabecular bone volume fraction of FPI-selenate rats was higher than FPI-vehicle rats (41.8%; p<0.01), however, femora from selenate-treated groups were shorter in length (4.3%; p<0.01) and had increased growth plate width (22.1%; p<0.01), indicating that selenate impaired long bone growth. pQCT analysis demonstrated that distal metaphyseal cortical thickness was decreased in TBI rats compared to shams (11.7%; p<0.05), however selenate treatment to TBI animals offset this reduction (p<0.05). At the midshaft we observed no differences in biomechanical measures. Conclusion: These are the first findings to indicate that mitigating TBI-induced neuropathology may have the added benefit of preventing osteoporosis and associated fracture risk following TBI.

Funding

This work was supported by grants to SRS and TJO from the NHMRC, a fellowship to SRS from CIHR, and funding from La Trobe University to BLG and SJM.

History

Publication Date

2016-12-01

Journal

Journal of Musculoskeletal and Neuronal Interactions

Volume

16

Issue

4

Pagination

8p. (p. 369-376)

Publisher

Hylonome Publications

ISSN

1108-7161

Rights Statement

© The Authors 2016. Published under the terms of Creative Common License CC BY-NC-SA 4.0 (Attribution-NonCommercial-ShareAlike).

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