56291_Uljarevic,M_2016.pdf (412.82 kB)
Short report: relationship between restricted and repetitive behaviours in children with autism spectrum disorder and their parents
journal contributionposted on 2022-03-29, 04:12 authored by Mirko UljarevicMirko Uljarevic, DW Evans, GA Alvares, AJO Whitehouse
Background: Restricted and repetitive behaviours (RRBs) constitute a core symptom domain of autism spectrum disorder (ASD). However, the nature of RRBs in the context of the Broader Autism Phenotype (BAP) is not well understood. In particular, the relationship between RRBs in ASD probands and their parents remains largely unexplored. The current study explored the link between parental RRBs, measured via Interest in Patterns and Resistance to Changes subscales of the Autism Quotient and their children's RRBs, measured via Autism Diagnostic Observation Schedule RRB standardized domain score. Findings: Having both parents within the top 20 % of their RRB scores was associated with an increase of RRB scores for their children; however, no parent-of-origin effects were identified. Although the trend was observed for both Interest in Patterns and Resistance to Changes subscale, it was only statistically significant for Interest in Patterns. Conclusions: This paper provides significant contribution to our understanding of association between RRBs in parents and their children with ASD. Future work should also address the BAP in distinct genetic subtypes (whole chromosome aneuploidies, single gene mutations, copy number variations) of neurodevelopmental and neuropsychiatric disorders that involve RRBs.
MU and GAA are funded by the Cooperative Research Centre for Living with Autism (Autism CRC), established and supported under the Australian Government's Cooperative Research Centres Program; AJOW is supported by a NHMRC Senior Research Fellowship (APP1077966); DWE has no support or funding related to this study to report.
Article NumberARTN 29
Pagination5p. (p. 1-5)
Rights Statement© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Science & TechnologyLife Sciences & BiomedicineGenetics & HeredityNeurosciencesNeurosciences & NeurologyAutismRepetitive behavioursBroader Autism PhenotypeParentsMULTIPLE-INCIDENCEINTERESTS DOMAINSYMPTOM DOMAINSPHENOTYPESIBLINGSFAMILIESPERSONALITYRISKAdolescentAdultAutism Spectrum DisorderChildChild BehaviorChild, PreschoolFemaleHumansMaleMiddle AgedPhenotypeStereotyped Behavior