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SARS-CoV-2 spike-derived peptides presented by HLA molecules

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journal contribution
posted on 15.06.2021, 01:35 by Andrea NguyenAndrea Nguyen, Christopher SzetoChristopher Szeto, Dhilshan Jayasinghe, Christian A Lobos, Hanim Halim, Dimitra ChatzileontiadouDimitra Chatzileontiadou, Emma GrantEmma Grant, Stephanie GrasStephanie Gras
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused significant morbidity and mortality worldwide. With the remarkable advances in medical research, vaccines were developed to prime the human immune system and decrease disease severity. Despite these achievements, the fundamental basis of immunity to the SARS-CoV-2 virus is still largely undefined. Here, we solved the crystal structure of three spike-derived peptides presented by three different HLA molecules, and determined the stability of the overall peptide–HLA complexes formed. The peptide presentation of spike-derived peptides can influence the way in which CD8+ T cells can recognise infected cells, clear infection, and therefore, control the outcome of the disease.

History

Publication Date

01/06/2021

Journal

Biophysica

Volume

1

Issue

2

Pagination

10p. (p. 194-203)

Publisher

MDPI AG

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The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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