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Risk of Subsequent HIV Infection following Sexually Transmissible Infections among Men Who Have Sex with Men

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posted on 2022-09-28, 23:40 authored by BL Harney, PA Agius, C El-Hayek, CK Fairley, EPF Chow, N Roth, BK Tee, D Leslie, G Tachedjian, M Hellard, M Stoové
Background: HIV and bacterial sexually transmissible infection (STI) notifications among men who have sex with men (MSM) have increased in Australia and many other countries. The relationship between HIV infection and other STIs has been demonstrated previously. However, the relationship between the cumulative history of STIs and subsequent HIV infection remains largely unexplored and limits our understanding of the mechanisms underpinning the elevated HIV risk. Methods: Data from HIV-negative MSM who attended high-HIV caseload primary care clinics in Melbourne, Australia, from 2007 to 2014 with 2 or more HIV and STI tests were included. Controlling for sexual behaviors self-reported at clinic visits, discrete time survival analyses using generalized linear modeling estimated the effect of an STI at the prior test event and the cumulative history of STIs (none, 1, 2, or more [repeated]) on risk of HIV infection. Results: A total of 8941 MSM met the study criteria; 227 (2.5%) were diagnosed with HIV over the follow-up period. Adjusting for sexual behaviors, a cumulative history of repeated rectal gonorrhea infections (adjusted hazard ratio [aHR], 6.27; 95% confidence interval [CI], 2.68-14.50) and a single rectal gonorrhea infection (aHR, 2.09; 95% CI, 1.15-3.79) were associated with increased HIV infection risk. Conclusions: Repeated and single rectal gonorrhea infections were independently associated with increased HIV infection risk. These findings suggest that MSM with any history of rectal gonorrhea, particularly repeat rectal gonorrhea, represent a group for whom preventive interventions for HIV should be emphasized.

Funding

Funding for VPCNSS was received from the Department of Health and Human Services, Victorian Government. Burnet Institute receives ongoing infrastructure support from the Victorian Government. C.K.F., E.P.F.C., M.S., G.T., and M.H. have received and/or currently receive personal fellowship funding from the Australian National Health and Medical Research Council.

History

Publication Date

2019-10-01

Journal

Open Forum Infectious Diseases

Volume

6

Issue

10

Article Number

ofz376

Pagination

7p.

Publisher

Oxford University Press

ISSN

2328-8957

Rights Statement

© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comDOI: 10.1093/ofid/ofz376

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