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Reduction in retained activity participation is associated with depressive symptoms 3 months after mild stroke: An observational cohort study

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posted on 2021-12-21, 04:59 authored by Tamara TseTamara Tse, Jacinta DouglasJacinta Douglas, P Lentin, T Lindén, L Churilov, H Ma, S Davis, G Donnan, Leeanne CareyLeeanne Carey
Objective: To quantify the association of depressive symptoms with retained activity participation 3 months post-stroke, after adjusting for neurological stroke severity and age. Design: A cross-sectional observational study of retained activity participation and depressive symptoms in stroke survivors with ischaemic stroke. Participants: One hundred stroke survivors with mild neurological stroke severity. Methods: One hundred stroke survivors were recruited from 5 metropolitan hospitals and reviewed at 3 months post-stroke using measures of activity participation, Activity Card Sort-Australia, and depressive symptoms, Montgomery-Asberg Depression Rating Scale Structured Interview Guide (MADRS-SIGMA). Results: The median percentage of retained overall activity participation was 97%, (interquartile range 79-100%). Using multiple median regression, 1 point increase in the MADRS-SIGMA was associated with a median decrease of 0.7% (95% CI -1.4 to -0.1, p=0.02) of retained overall activity participation, assuming similar neurological stroke severity and age. Conclusion: The findings of this study establish the association of depressive symptoms with retained activity participation 3 months post-stroke in stroke survivors with mild neurological stroke severity. Clinical rehabilitation recommendations to enhance activity participation need to account for those with even mild depressive symptoms post-stroke.


Financial support for the research was received from the Commonwealth Scientific and Industrial Research Organization (CSIRO) of Australia, Flagship Collaboration Fund through the Preventative Health Flagship; and support for analysis, write up and researchers from the Victorian Government's Operational Infrastructure Support Program; James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation-Collaborative Award (#220020413); NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury (APP1077898); an Australian Research Council Future Fellowship awarded to LMC [#FT0992299]; and a La Trobe University Post Graduate Scholarship and Florey student scholarship awarded to TT.


Publication Date



Journal of Rehabilitation Medicine






8p. (p. 120-127)


Taylor & Francis



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