Recruitment and baseline characteristics of young adults at risk of early-onset knee osteoarthritis after ACL reconstruction in the SUPER-Knee trial

Culvenor, Adam; West, Thomas; Bruder, Andrea; Scholes, Mark; Barton, Christian; Roos, Ewa; Oei, Edwin HG; McPhail, Steven M; Souza, Richard B; Lee, Jusuk; Patterson, Brooke; Girdwood, Michael; Couch, Jamon; Crossley, Kay

doi:10.26181/25623426.v1

Recruitment and baseline characteristics of young adults at risk of early-onset knee osteoarthritis after ACL reconstruction in the SUPER-Knee trial

journal contribution

posted on 2024-04-17, 06:22 authored by Adam CulvenorAdam Culvenor, Thomas WestThomas West, Andrea BruderAndrea Bruder, Mark ScholesMark Scholes, Christian BartonChristian Barton, Ewa RoosEwa Roos, Edwin HG Oei, Steven M McPhail, Richard B Souza, Jusuk Lee, Brooke PattersonBrooke Patterson, Michael GirdwoodMichael Girdwood, Jamon CouchJamon Couch, Kay CrossleyKay Crossley

OBJECTIVES: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. METHODS: The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4)) 9-36 months post-ACLR. The NNS was calculated as the number of prospective participants screened to enrol one person. At baseline, participants provided medical history, completed questionnaires (demographic, injury/surgery, rehabilitation characteristics) and underwent physical examination. RESULTS: 1044 individuals were screened to identify 567 eligible people, from which 184 participants (63% male) enrolled. The sample of enrolled participants was multicultural (29% born outside Australia; 2% Indigenous Australians). The NNS was 5.7. For randomised participants, mean±SD age was 30±6 years. The mean body mass index was 27.3±5.2 kg/m2, with overweight (43%) and obesity (21%) common. Participants were, on average, 2.3 years post-ACLR. Over half completed <8 months of postoperative rehabilitation, with 56% having concurrent injury/surgery to meniscus and/or cartilage. The most affected KOOS (0=worst, 100=best) subscale was quality of life (mean 43.7±19.1). CONCLUSION: Young adults post-ACLR were willing to participate in a secondary osteoarthritis prevention trial. Sample size calculations should be multiplied by at least 5.7 to provide an estimate of the NNS. The SUPER-Knee cohort is ideally positioned to monitor and intervene in the early development and trajectory of osteoarthritis.

Funding

This trial is supported by the National Health and Medical Research Council (NHMRC) of Australia (GNT1158500). AGC is a recipient of an NHMRC Investigator Grant (GNT2008523). MAG is supported by an NHMRC Post Graduate award (GNT1190882). PC is a recipient of an NHMRC Practitioner Fellowship (GNT1154203).

History

Publication Date

2024-04-04

Journal

BMJ Open Sport & Exercise Medicine

Volume

10

Issue

2

Article Number

e001909

Pagination

9p.

Publisher

BMJ Publishing Group

ISSN

2055-7647

Rights Statement

© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.