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Recent discoveries on the involvement of Krüppel-like factor 4 in the most common cancer types
journal contributionposted on 18.01.2021, 04:10 by A Taracha-Wisniewska, G Kotarba, Sebastian Dworkin, T Wilanowski
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in cancer. The results of most studies suggest that KLF4 is a tumor suppressor. However, the functioning of KLF4 is regulated at many levels. These include regulation of transcription, alternative splicing, miRNA, post-translational modifications, subcellular localization, protein stability and interactions with other molecules. Simple experiments aimed at assaying transcript levels or protein levels fail to address this complexity and thus may deliver misleading results. Tumor subtypes are also important; for example, in prostate cancer KLF4 is highly expressed in indolent tumors where it impedes tumor progression, while it is absent from aggressive prostate tumors. KLF4 is important in regulating response to many known drugs, and it also plays a role in tumor microenvironment. More and more information is available about upstream regulators, downstream targets and signaling pathways associated with the involvement of KLF4 in cancer. Furthermore, KLF4 performs critical function in the overall regulation of tissue homeostasis, cellular integrity, and progression towards malignancy. Here we summarize and analyze the latest findings concerning this fascinating transcription factor.
This research was funded by the National Science Centre (grant number 2016/21/B/NZ1/00279), funded by the Polish government.
JournalInternational Journal of Molecular Sciences
Pagination28p. (p. 1-28)
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, MultidisciplinaryChemistrybreast cancercolorectal cancergastric cancerhepatocellular carcinomaKLF4lung cancermicroenvironmentprostate cancersubcellular localizationtranscription factorACIDIC TUMOR MICROENVIRONMENTTO-MESENCHYMAL TRANSITIONSMOOTH-MUSCLE-CELLSCOLORECTAL-CANCERBREAST-CANCERHEPATOCELLULAR-CARCINOMAKLF4 EXPRESSIONDOWN-REGULATIONCONDITIONAL DELETIONSIGNALING PATHWAYChemical Physics