Version of record: https://onlinelibrary.wiley.com/doi/10.1002/asia.202100102
Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics where their clinical efficacy is dwindling due to the emergence of antimicrobial resistance (AMR). Accompanying with the development of AMPs, a number of fluorescent probes have been developed to facilitate the understanding the modes of action of AMPs. These probes have been used to monitor the binding process, determine the working mechanism and evaluate the antimicrobial properties of AMPs. In particular, with the recent advance of aggregation-induced emission (AIE) fluorophores, that show many advantageous properties over traditional probes, there is an increasing research interest in using AIE probes for AMP studies. In this review, we give an overview of AMP development, highlight the recent progress of using fluorescence probes in particularly AIE probes in the AMP field and propose the future perspective of developing potent antimicrobial agents to combat AMR.
This work was supported by grants to Y.H. (Australia-China Science and Research Fund-Joint Research Centre for Personal Health Technologies ACSRF65777 and La Trobe University Research Focus Area Grant 2000004375), to W.L. (University of Melbourne Early Career Researcher Grant, Weary Dunlop Foundation Grant and Australian Dental Research Foundation Grant 2545-2020), to N.M.O-S NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP210102781, DP160101312, LE200100163), Cancer Council Victoria funding (APP1163284) and Australian Dental Research Funding in antimicrobial materials and research is supported by the Centre for Oral Health Research at The Melbourne Dental School.
Chemistry - An Asian Journal
This is the peer reviewed version of the following article: Luu, Tracey & Li, Wenyi & O'Brien-Simpson, Neil & Hong, Yuning. (2021). Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies. Chemistry - An Asian Journal. 16. 10.1002/asia.202100102, which has been published in final form at https://onlinelibrary.wiley.com/doi/10.1002/asia.202100102. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. Any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.