La Trobe
1176577_Buyadaa,O_2021.pdf (782.98 kB)

Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes

Download (782.98 kB)
journal contribution
posted on 17.08.2021, 07:57 by O Buyadaa, Agus SalimAgus Salim, JI Morton, DJ Magliano, Jonathan ShawJonathan Shaw
The association between rate of kidney function decline and age-of-onset or duration of diabetes has not been well investigated. We aimed to examine whether rates of estimated glomerular filtration rate (eGFR) decline differ by age-of-onset or duration in people with type 2 diabetes. Using the Action to Control Cardiovascular Risk in Diabetes study which included those with HbA1c ≥ 7.5% and who were at high risk of cardiovascular events, rates of eGFR decline were calculated and were compared among groups defined by the known age-of-onset (0–39, 40–49, 50–59, 60–69 and > 70 years) and 5-year diabetes duration intervals. Changes in renal function were evaluated using median of 6 (interquartile range 3–10) eGFR measurements per person. eGFR decline was the slowest in those with known age-at-diagnosis of 50–59 years or those with duration of diabetes < 5 years. The rates of eGFR decline were significantly greater in those with known age-of-onset < 40 years or those with duration of diabetes > 20 years compared to those diagnosed at 50–59 or those with duration of diabetes < 5 years (− 1.98 vs − 1.61 mL/min/year; − 1.82 vs − 1.52 mL/min/year; respectively (p < 0.001). Those with youngest age-of-onset or longer duration of diabetes had more rapid declines in eGFR compared to those diagnosed at middle age or those with shorter duration of diabetes.

Funding

OB is supported by a Monash University Postgraduate Research Scholarship and a Baker Bright Sparks Scholarship. J.I.M is supported by an Australian Government Research Training Program (RTP) Scholarship and Monash Graduate Excellence Scholarship. JES is supported by a National Health and Medical Research Council Investigator Grant and DJM by a National Health and Medical Research Council Senior Research Fellowship. This work is partially supported by the Victorian Government's OIS Program.

History

Publication Date

19/07/2021

Journal

Scientific Reports

Volume

11

Article Number

14705

Pagination

8p.

Publisher

Nature Portfolio

ISSN

2045-2322

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.