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Proteomics-driven cancer biomarker discovery looking to the future_Simpson_COCB_Revised_Feb1_2008.pdf (247.96 kB)

Proteomics-driven cancer biomarker discovery: looking to the future

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journal contribution
posted on 12.08.2021, 06:41 by Richard SimpsonRichard Simpson, OK Bernhard, David GreeningDavid Greening, RL Moritz
Availability of a suite of biomarkers for early detection, stratification into distinct subtypes, and monitoring progression or response to therapy promises significant improvements in clinical outcomes for cancer patients. However, despite the recent progress in proteomics technologies based on mass spectrometry (MS), discovery of novel clinical assessment tools has been slow. This is, partly due to the inherent difficulties in working with blood as the biospecimen for candidate discovery. A better understanding of the limitations of blood for comparative protein profiling and a better appreciation of the advantages of cancer tissue or cancer cell secretomes have the potential to greatly enhance the progress. Crown Copyright © 2008.

History

Publication Date

01/02/2008

Journal

Current Opinion in Chemical Biology

Volume

12

Issue

1

Pagination

(p. 72-77)

Publisher

CURRENT BIOLOGY LTD

ISSN

1367-5931

Rights Statement

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