La Trobe

File(s) stored somewhere else

Please note: Linked content is NOT stored on La Trobe and we can't guarantee its availability, quality, security or accept any liability.

Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?

journal contribution
posted on 18.12.2020, 01:57 by Nordin MJ Hanssen, Michael J Kraakman, Michelle C Flynn, Prabhakara R Nagareddy, Casper G Schalkwijk, Andrew Murphy
Clinical trials investigating whether glucose lowering treatment reduces the risk of CVD in diabetes have thus far yielded mixed results. However, this doesn't rule out the possibility of hyperglycemia playing a major causal role in promoting CVD or elevating CVD risk. In fact, lowering glucose appears to promote some beneficial long-term effects, and continuous glucose monitoring devices have revealed that postprandial spikes of hyperglycemia occur frequently, and may be an important determinant of CVD risk. It is proposed that these short, intermittent bursts of hyperglycemia may have detrimental effects on several organ systems including the vasculature and the hematopoietic system collectively contributing to the state of elevated CVD risk in diabetes. In this review, we summarize the potential mechanisms through which hyperglycemic spikes may increase atherosclerosis and how new and emerging interventions may combat this.

Funding

NH was supported by the Dutch Heart foundation (2017T039), Dutch Diabetes foundation (2017.85.005), and the EFSD. PN was funded by a NIH Pathway to Independence Award (1K99HL122505-01). AM was supported by a CSL Centenary Award.

History

Publication Date

18/09/2020

Journal

Frontiers in Cardiovascular Medicine

Volume

7

Article Number

ARTN 570553

Pagination

11p. (p. 1-11)

Publisher

Frontiers Research Foundation

ISSN

2297-055X

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.