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Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?
journal contributionposted on 18.12.2020, 01:57 by Nordin MJ Hanssen, Michael J Kraakman, Michelle C Flynn, Prabhakara R Nagareddy, Casper G Schalkwijk, Andrew Murphy
Clinical trials investigating whether glucose lowering treatment reduces the risk of CVD in diabetes have thus far yielded mixed results. However, this doesn't rule out the possibility of hyperglycemia playing a major causal role in promoting CVD or elevating CVD risk. In fact, lowering glucose appears to promote some beneficial long-term effects, and continuous glucose monitoring devices have revealed that postprandial spikes of hyperglycemia occur frequently, and may be an important determinant of CVD risk. It is proposed that these short, intermittent bursts of hyperglycemia may have detrimental effects on several organ systems including the vasculature and the hematopoietic system collectively contributing to the state of elevated CVD risk in diabetes. In this review, we summarize the potential mechanisms through which hyperglycemic spikes may increase atherosclerosis and how new and emerging interventions may combat this.
NH was supported by the Dutch Heart foundation (2017T039), Dutch Diabetes foundation (2017.85.005), and the EFSD. PN was funded by a NIH Pathway to Independence Award (1K99HL122505-01). AM was supported by a CSL Centenary Award.
JournalFrontiers in Cardiovascular Medicine
Article NumberARTN 570553
Pagination11p. (p. 1-11)
PublisherFrontiers Research Foundation
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicineCardiac & Cardiovascular SystemsCardiovascular System & CardiologydiabetehyperglyacemiainflammationRAGE (receptor for advanced glycation end products)hematopoeisGLYCATION END-PRODUCTSALL-CAUSE MORTALITYHUMAN ATHEROSCLEROTIC PLAQUESGLUCAGON-LIKE PEPTIDE-1FOLLOW-UPGLYCEMIC CONTROLPLASMA-LEVELSRISK-FACTORHYPERGLYCEMIATYPE-1