1154695_Sreejit,G_2020.pdf (1.08 MB)
Origins and diversity of macrophages in health and disease
journal contribution
posted on 2021-01-29, 00:41 authored by G Sreejit, AJ Fleetwood, Andrew MurphyAndrew Murphy, PR Nagareddy© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our understanding of these cells has evolved from being thought of as simple phagocytic cells to master regulators involved in governing a myriad of cellular processes. A better appreciation of macrophage biology has been matched with a clearer understanding of their diverse origins and the flexibility of their metabolic and transcriptional machinery. The understanding of the classical mononuclear phagocyte system in its original form has now been expanded to include the embryonic origin of tissue-resident macrophages. A better knowledge of the intrinsic similarities and differences between macrophages of embryonic or monocyte origin has highlighted the importance of ontogeny in macrophage dysfunction in disease. In this review, we provide an update on origin and classification of tissue macrophages, the mechanisms of macrophage specialisation and their role in health and disease. The importance of the macrophage niche in providing trophic factors and a specialised environment for macrophage differentiation and specialisation is also discussed.
Funding
This work was supported by NIH funding to PRN (HL137799).
History
Publication Date
2020-12-20Journal
Clinical and Translational ImmunologyVolume
9Issue
12Article Number
e1222Pagination
19p.Publisher
WileyISSN
2050-0068Rights Statement
The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.Publisher DOI
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Science & TechnologyLife Sciences & BiomedicineImmunologyinnate immunitymacrophage diversitymacrophage functionsmacrophage nichemacrophage originsCOLONY-STIMULATING FACTOR-1TISSUE-RESIDENT MACROPHAGESTUMOR-ASSOCIATED MACROPHAGESGENE-EXPRESSION PROFILESLANGERHANS CELLSBONE-MARROWYOLK-SACSTEADY-STATEMETABOLIC-REGULATIONANALYSIS REVEALS