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Origins and diversity of macrophages in health and disease

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journal contribution
posted on 29.01.2021, 00:41 by G Sreejit, AJ Fleetwood, Andrew MurphyAndrew Murphy, PR Nagareddy
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our understanding of these cells has evolved from being thought of as simple phagocytic cells to master regulators involved in governing a myriad of cellular processes. A better appreciation of macrophage biology has been matched with a clearer understanding of their diverse origins and the flexibility of their metabolic and transcriptional machinery. The understanding of the classical mononuclear phagocyte system in its original form has now been expanded to include the embryonic origin of tissue-resident macrophages. A better knowledge of the intrinsic similarities and differences between macrophages of embryonic or monocyte origin has highlighted the importance of ontogeny in macrophage dysfunction in disease. In this review, we provide an update on origin and classification of tissue macrophages, the mechanisms of macrophage specialisation and their role in health and disease. The importance of the macrophage niche in providing trophic factors and a specialised environment for macrophage differentiation and specialisation is also discussed.

Funding

This work was supported by NIH funding to PRN (HL137799).

History

Publication Date

20/12/2020

Journal

Clinical and Translational Immunology

Volume

9

Issue

12

Article Number

e1222

Pagination

19p.

Publisher

Wiley

ISSN

2050-0068

Rights Statement

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