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Optimising molecular rotors to AIE fluorophores for mitochondria uptake and retention

journal contribution
posted on 10.09.2021, 01:44 by TC Owyong, Siyang DingSiyang Ding, N Wu, T Fellowes, S Chen, JM White, WWH Wong, Yuning HongYuning Hong
Molecular rotors exhibit fluorescence enhancement in a confined environment and thus have been used extensively in biological imaging. However, many molecular rotors suffer from small Stokes shift and self-aggregation caused quenching. In this work, we have synthesised a series of red emissive molecular rotors based on cationic α-cyanostilbene. Profoundly enhanced aggregation-induced emission (AIE) properties and greatly widened Stokes shifts can be achieved by molecular engineering. With specificity to stain mitochondria, we demonstrate a simple approach to achieve cell uptake and retention upon tuning the pyridinium substituent of the dyes.

Funding

We thank LIMS Bioimaging Platform, La Trobe University for the access to confocal microscope and the Bio21 Mass Spectrometry and Proteomics Facility for technical support and access to mass spectrometers. This work was supported by grants to Y. H. (Australian Research Council DE170100058, Rebecca L. Cooper Medical Research Foundation PG2018043, and Australia-China Science and Research Fund-Joint Research Centre for Personal Health Technologies ACSRF65777) and WWHW (Australian Research Council CE170100026).

History

Publication Date

07/12/2020

Journal

Chemical Communications

Volume

56

Issue

94

Pagination

4p. (p. 14853-14856)

Publisher

Royal Society of Chemistry

ISSN

1359-7345

Rights Statement

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