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Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study

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posted on 2021-01-12, 22:44 authored by Harvi HartHarvi Hart, Marienke van Middelkoop, Joshua J Stefanik, Kay CrossleyKay Crossley, Sita Bierma-Zeinstra
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. To determine the longitudinal association of baseline body mass index and change in body mass index over 8 years to incident of patellofemoral osteoarthritis at the 8-year follow-up. A sample of 528 women and men, aged 45–65 years, with knee complaints and without radiographic evidence of patellofemoral and tibiofemoral osteoarthritis at baseline, were selected from the Cohort Hip and Cohort Knee cohort. Incidence of patellofemoral osteoarthritis was defined as presence of radiographic patellofemoral osteoarthritis (with or without tibiofemoral osteoarthritis) at the 8-year follow-up. Baseline body mass index data were categorized into normal, overweight, and obese weight-categories. Logistic regression analyses, adjusted for age and sex, were conducted to determine the association of baseline body mass index and change in body mass index to patellofemoral osteoarthritis incidence 8 years later. Obesity was associated with greater odds of radiographic patellofemoral osteoarthritis incident (odds ratio: 1.8 [95% CI 1.1, 3.1]) 8 years later. There were no significant associations observed between body mass index change over 8 years and incidence of radiographic patellofemoral osteoarthritis in overweight and obese individuals. Obesity is associated with increased odds of developing radiographic patellofemoral osteoarthritis 8 years later.


The Cohort Hip and Cohort Knee study is funded by the Dutch Arthritis Foundation. Involved are: Erasmus Medical Center Rotterdam; Kennemer Gasthuis Haarlem; Leiden University Medical Center; Maastricht University Medical Center; Martini Hospital Groningen/Allied Health Care Center for Rheumatology and Rehabilitation Groningen; Medical Spectrum Twente Enschede/Ziekenhuisgroep Twente Almelo; Reade Center for Rehabilitation and Rheumatology; St. Maartens-kliniek Nijmegen; University Medical Center Utrecht; Wilhelmina Hospital Assen. Funding sources had no role in the study design, collection, analysis, and interpretation of the data or the decision to submit the manuscript for publication. All co-authors take full responsibility for the integrity for all aspects of the study and the final manuscript. This material was submitted as an abstract and presented at the 2019 OARSI World Congress on Osteoarthritis.The Medical Ethics Committee (The Netherlands) Approval Number 02/017-E.


Publication Date



Rheumatology International






6p. (p. 227-232)


Springer Nature



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