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New Cellular Dimensions on Glioblastoma Progression.pdf (352.05 kB)

New cellular dimensions on glioblastoma progression

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journal contribution
posted on 18.01.2021, 03:35 by Marta Portela-Esteban, S Casas-Tintó
© The Author(s) 2020. Gliomas are brain tumors originated from glial cells. The most frequent form of glioma is the glioblastoma (GB). This lethal tumor is frequently originated from genetic alterations in epidermal growth factor receptor (EGFR) and PI3K pathways. Recent results suggest that signaling pathways, other than primary founder mutations, play a central role in GB progression. Some of these signals are depleted by GB cells from healthy neurons via specialized filopodia known as tumor microtubes (TMs). Here, we discuss the contribution of TMs to vampirize wingless/WNT ligand from neurons. In consequence, wingless/WNT pathway is upregulated in GB to promote tumor progression, and the reduction of these signals in neurons causes the reduction of synapse number and neurodegeneration. These processes contribute to neurological defects and premature death.

History

Publication Date

01/01/2020

Journal

Neuroscience Insights

Volume

15

Article Number

UNSP 2633105520923076

Pagination

4p.

Publisher

Sage Publications

ISSN

2633-1055

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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