Neuropathic Symptoms and Frequency of Chronic Pain in an International Online Sample of Individuals with Sub-Acute and Chronic Stroke

Background/Objectives: Chronic pain is common following a stroke and is associated with increased disability. Yet, little is known about the chronic pain experience in the stroke population. This study aimed to identify and explore the features and neuropathic symptoms of chronic pain in individuals with longstanding stroke.

Methods: This observational study utilized an online survey that was developed for individuals who have had a stroke (>3 months). Data sought included participant demographics, medical history, and details of the stroke(s). Participants who reported experiencing chronic pain completed the Numerical Rating Scale for Pain, the Neuropathic Pain Symptom Inventory, and body maps to indicate region(s) of pain.

Results: A total of 533 individuals with longstanding stroke participated. Chronic pain was reported as being experienced by 60% of participants and was more frequently experienced by individuals who reported being female (p = 0.002). Moderate or severe pain intensity was commonly reported (mean = 5.98, SD = 1.89). Individuals with chronic pain post-stroke reported a range of neuropathic symptoms rather than a common pain experience, with combinations of spontaneous, paroxysmal, and evoked pains in addition to pain associated with paraesthesia/dysaesthesia. Pain involving the upper limb was the most common region (shoulder 39%, hand and forearm 38%), followed by the lower limb (foot 30%, leg 29%). Having multiple strokes was associated with a higher frequency of chronic pain (p = 0.01), as was peripheral vascular disease (p < 0.001) and lipid disorders (p = 0.001).

Conclusions: These findings highlight the varied nature of chronic pain experienced by individuals following a stroke, while also detailing stroke and medical history associated with chronic pain. It builds on existing knowledge of chronic pain post-stroke and provides new insight into the neuropathic symptoms experienced. This knowledge has the potential to assist in the development of tailored interventions based on addressing pain symptomatology and health literacy.