Modular synthesis of functional libraries by accelerated SuFEx click chemistry

J. E. M. is grateful to the NCI Cancer Center (support grant 5P30CA045508), the Cold Spring Harbor Laboratory (CSHL) Northwell Health Affiliation, the F. M. Kirby Foundation, the Sunshine Foundation, S. J. Edwards, the Starr Foundation, Swim Across America Inc., the Wasily Family Foundation, the Australian Research Council (Future Fellowship; FT170100156), and La Trobe University for generous support. This work was performed with assistance from the CSHL Organoid Shared Resource and the CSHL Mass Spectrometry and Metabolomics Shared Resource, both partly supported by Cancer Center Support Grant 5P30CA045508 from the National Cancer Institute. M. J. L. is supported by METAvivor (and W.-H. Y.), the Department of Defense Breast Cancer Research Program (BC200599), and the National Institutes of Health (R01GM149957 and 5P30CA045508). The Lustgarten Foundation supported D. A. T, A. N. H, and all organoid work. A. N. H is also supported by a Postdoctoral Fellowship (PF-23-1036459-01-ET) from the American Cancer Society. E. F. L. is supported by a Victorian Cancer Agency Mid-Career Fellowship (MCRF19045). J. A. H. and C. A. are funded by The New York Community Trust's Heiser Program. Z. B. and A. E. P. are supported by the European Union H2020-MSCA-ITN-2019 860070 TUBINTRAIN. M. O. S. is supported by the Swiss National Science Foundation (310030_192566). C. A. and M. J. thank Dr Anthony Baughn from the University of Minnesota for providing the M. tuberculosis strain mc27000 Delta pabC. D. B. is funded by Prof. Michael Wigler. The authors would also like to thank Dr Qinheng Zheng for insightful discussions and Dr Christopher Smedley for supervising T. L. G. in the laboratory. While preparing this work, the authors used ChatGPT 4.0 and Grammarly to improve readability. After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.