Modelling Cooperative Tumorigenesis in Drosophila
journal contributionposted on 29.01.2021, 00:59 by Helena RichardsonHelena Richardson, Marta Portela-EstebanMarta Portela-Esteban
© 2018 Helena E. Richardson and Marta Portela. The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
JournalBioMed Research International
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
Science & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyMedicine, Research & ExperimentalResearch & Experimental MedicineTUMOR-SUPPRESSOR ACTIVITYAPOPTOSIS-INDUCED PROLIFERATIONCHROMATIN-REMODELING COMPLEXCELL COMPETITIONHIPPO PATHWAYIMAGINAL DISCSTISSUE-GROWTHONCOGENIC RASCOMPENSATORY PROLIFERATIONNEOPLASTIC TRANSFORMATIONAnimalsHumansDrosophila melanogasterNeoplasmsDrosophila ProteinsGenes, Tumor SuppressorOncogenesCarcinogenesis