Modelling Cooperative Tumorigenesis in Drosophila
© 2018 Helena E. Richardson and Marta Portela. The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
JournalBioMed Research International
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Science & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyMedicine, Research & ExperimentalResearch & Experimental MedicineTUMOR-SUPPRESSOR ACTIVITYAPOPTOSIS-INDUCED PROLIFERATIONCHROMATIN-REMODELING COMPLEXCELL COMPETITIONHIPPO PATHWAYIMAGINAL DISCSTISSUE-GROWTHONCOGENIC RASCOMPENSATORY PROLIFERATIONNEOPLASTIC TRANSFORMATIONAnimalsHumansDrosophila melanogasterNeoplasmsDrosophila ProteinsGenes, Tumor SuppressorOncogenesCarcinogenesis