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Mediterranean diet decreases the initiation of use of vitamin K epoxide reductase inhibitors and their associated cardiovascular risk: a randomized controlled trial

journal contribution
posted on 18.01.2021, 03:11 by Sara Castro-Barquero, Margarita Ribó-Coll, Camille Lassale, Anna Tresserra-Rimbau, Olga Castañer, Xavier Pintó, Miguel Martinez-Gonzalez, José V Sorlí, Jordi Salas-Salvadó, José Lapetra, Enrique Gómez-Gracia, Ángel M Alonso-Gómez, Miquel Fiol, Lluis Serra-Majem, Emilio Sacanella, Francisco Javier Basterra-Gortari, Olga Portolés, Nancy Babio, Montserrat Cofán, Emilio Ros, Ramón Estruch, Álvaro Hernáez
Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46-0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92-9.30], HRMedDiets: 1.71 [0.83-3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.

History

Publication Date

19/12/2020

Journal

Nutrients

Volume

12

Issue

12

Article Number

3895

Pagination

14p. (p. 1-14)

Publisher

MDPI

ISSN

2072-6643

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

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