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Low dietary magnesium and overweight/obesity in a Mediterranean population: a detrimental synergy for the development of hypertension. The SUN project

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posted on 26.03.2021, 04:35 by LJ Dominguez, A Gea, L Ruiz-Estigarribia, C Sayón-Orea, U Fresán, M Barbagallo, M Ruiz-Canela, Miguel Martinez-Gonzalez
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Hypertension is the strongest independent modifiable risk factor for cardiovascular dis-ease. We aimed to investigate the association of magnesium intake with incident hypertension in a Mediterranean population, and the potential modification of this association by body mass index BMI. We assessed 14,057 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (67.0% women) initially free of hypertension. At baseline, a validated 136-item food frequency questionnaire was administered. We used Cox models adjusted for multiple socio-demographic, anthropometric, and lifestyle factors, and prevalent conditions present at baseline. Among a mean 9.6 years of follow-up we observed 1406 incident cases of medically diagnosed hypertension. An in-verse association in multivariable-adjusted models was observed for progressively higher magnesium intake up to 500 mg/d vs. intake < 200 mg/d, which was greater among those with a BMI > 27 kg/m2 . Lean participants with magnesium intake < 200 mg/d vs. >200 mg/d also had a higher risk of incident hypertension. Adherence to the Mediterranean diet did not modify these associations. In conclusion, dietary magnesium intake < 200 mg/d was independently associated with a higher risk of developing hypertension in a Mediterranean cohort, stronger for overweight/obese participants. Our results emphasize the importance of encouraging the consumption of magnesium-rich foods (vegetables, nuts, whole cereals, legumes) in order to prevent hypertension.

Funding

The SUN Project has received funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045), CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, and PI17/01795. The funding sources had no role in the study design, data collection, analysis and interpretation of data, writing of the report, or the decision to submit the article for publication.

History

Publication Date

01/01/2021

Journal

Nutrients

Volume

13

Issue

1

Article Number

125

Pagination

17p. (p. 1-17)

Publisher

MDPI

ISSN

2072-6643

Rights Statement

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