This study was supported by a La Trobe University, Special Strategic Grant (2021). AGC is a recipient of a National Health and Medical Research Council (NHMRC) of Australia Investigator Grant (GNT2008523). JLK is a recipient of a National Health and Medical Research Council (NHMRC) of Australia Investigator Grant (GNT2017844). JLW is supported by a Michael Smith Foundation for Health Research a Scholar Award (SCH- 2020-0403) and an Arthritis Society STAR Career Development Award (STAR - 19-0493). This research was funded in part by the National Health and Medical Research Council (GNT2008523).