Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

Paolini, Lucia; Monguió‐Tortajada, Marta; Costa, Marta; Antenucci, Fabio; Barilani, Mario; Clos‐Sansalvador, Marta; Andrade, André Cronemberger; Driedonks, Tom AP; Giancaterino, Sara; Kronstadt, Stephanie M; Mizenko, Rachel R; Nawaz, Muhammad; Osteikoetxea, Xabier; Pereira, Carla; Shrivastava, Surya; Boysen, Anders Toftegaard; van de Wakker, Simonides Immanuel; van Herwijnen, Martijn JC; Wang, Xiaoqin; Watson, Dionysios C; Gimona, Mario; Liaskos, Maria; Konstantinov, Konstantin; Lim, Sai Kiang; Meisner‐Kober, Nicole; Stork, Michiel; Nejsum, Peter; Radeghieri, Annalisa; Rohde, Eva; Touzet, Nicolas; Wauben, Marca HM; Witwer, Kenneth W; Bongiovanni, Antonella; Bergese, Paolo

doi:10.26181/25864834.v1

1643980_Paolini,L_2022.pdf (480.1 kB)

Large‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop

journal contribution

posted on 2024-05-21, 02:05 authored by Lucia Paolini, Marta Monguió‐Tortajada, Marta Costa, Fabio Antenucci, Mario Barilani, Marta Clos‐Sansalvador, André Cronemberger Andrade, Tom AP Driedonks, Sara Giancaterino, Stephanie M Kronstadt, Rachel R Mizenko, Muhammad Nawaz, Xabier Osteikoetxea, Carla Pereira, Surya Shrivastava, Anders Toftegaard Boysen, Simonides Immanuel van de Wakker, Martijn JC van Herwijnen, Xiaoqin Wang, Dionysios C Watson, Mario Gimona, Maria LiaskosMaria Liaskos, Konstantin Konstantinov, Sai Kiang Lim, Nicole Meisner‐Kober, Michiel Stork, Peter Nejsum, Annalisa Radeghieri, Eva Rohde, Nicolas Touzet, Marca HM Wauben, Kenneth W Witwer, Antonella Bongiovanni, Paolo Bergese

Abstract: Extracellular vesicles (EVs) large-scale production is a crucial point for the translation of EVs from discovery to application of EV-based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET-OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor-made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV-based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.

Funding

The workshop was supported by: International Society for Extracellular Vesicles (ISEV); University of Brescia under “Funds for international activities” from the Italian Ministry of University and Research; evFOUNDRY project, Horizon 2020-Future and emerging technologies (H2020- FET-OPEN), ID: 801367; VES4US project Horizon 2020-Future and emerging technologies (H2020-FET-OPEN), ID: 801338; Italian Society for Extracellular Vesicles (EVIta).

History

Publication Date

2022-10-25

Journal

Journal of Extracellular Biology

Volume

1

Issue

10

Pagination

12p.

Publisher

Wiley

ISSN

2768-2811

Rights Statement

© 2022 The Authors. Journal of Extracellular Biology published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles. This is an open access article under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.