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Investigating the feasibility and ethical implications of phenotypic screening using stem cell-derived tissue models to detect and manage disease.

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journal contribution
posted on 26.05.2022, 05:43 authored by Alexander R Harris, Mary WalkerMary Walker, Frederic Gilbert, Patrick McGivern
Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient displays symptoms, allowing for their use as a disease screening tool. This raises numerous issues, some of which can be addressed using similar approaches from genetic screenings, while others are unique. One issue is the relationship between disease disposition, biomarker detection, and patient symptoms and how tissue models could be used to define disease. Other issues include decisions of when to screen, what diseases to screen for, and what treatment options should be offered.

History

Publication Date

01/01/2022

Journal

Stem Cell Reports

Volume

17

Issue

5

Pagination

10p. (p. 1023-1032)

Publisher

Elsevier

ISSN

2213-6711

Rights Statement

© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).