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Intracortical circuits in the contralesional primary motor cortex in patients with chronic stroke after botulinum toxin type A injection: case studies
journal contributionposted on 2020-11-06, 00:47 authored by Maryam ZoghiMaryam Zoghi, P Hafezi, B Amatya, F Khan, MP Galea
© Copyright © 2020 Zoghi, Hafezi, Amatya, Khan and Galea. Spasticity and motor recovery are both related to neural plasticity after stroke. A balance of activity in the primary motor cortex (M1) in both hemispheres is essential for functional recovery. In this study, we assessed the intracortical inhibitory and facilitatory circuits in the contralesional M1 area in four patients with severe upper limb spasticity after chronic stroke and treated with botulinum toxin-A (BoNT-A) injection and 12 weeks of upper limb rehabilitation. There was little to no change in the level of spasticity post-injection, and only one participant experienced a small improvement in arm function. All reported improvements in quality of life. However, the levels of intracortical inhibition and facilitation in the contralesional hemisphere were different at baseline for all four participants, and there was no clear pattern in the response to the intervention. Further investigation is needed to understand how BoNT-A injections affect inhibitory and facilitatory circuits in the contralesional hemisphere, the severity of spasticity, and functional improvement.
JournalFrontiers in Human Neuroscience
PublisherFrontiers Media SA
Rights StatementThe Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.
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Science & TechnologySocial SciencesLife Sciences & BiomedicineNeurosciencesPsychologyNeurosciences & Neurologystrokeprimary motor cortexcontralesionalcase studiesintracortical circuitsspasticbotulinum A toxinTRANSCRANIAL MAGNETIC STIMULATIONSPASTICITY FOLLOWING STROKEQUALITY-OF-LIFEUNAFFECTED HEMISPHEREINTERRATER RELIABILITYCORTICAL DISINHIBITIONASHWORTH SCALEARM SPASTICITYTARDIEU SCALEHUMAN HANDExperimental Psychology