The distribution of population between metropolitan regions and their rural counterparts is a topic of interest, due to the growth pressures in large cities and areas of decline in some, typically remote regions. In Australia, fostering population growth in regional urban centres (RUCs) has been a long-term goal of government policy. Understanding the different profiles, structures, and population dynamics of Australia's RUCs is critical in informing Australian regional development, as well as factors in regional population dynamics in general. This research is focused on patterns of population change through internal migration across Australian RUCs. In addition to a detailed spatial analysis of patterns of population migration flows, this research offers a comprehensive analysis of a range of regional social, economic and infrastructure development factors and their effects on regional migration and population changes. The outputs of the method are new evidence to inform the future regional plan to increase economic and population growth in RUCs. This research contributes to population research and regional planning and provides a baseline for the prepandemic status of regional population dynamics in Australia.