La Trobe

Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial

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posted on 2023-06-21, 02:08 authored by Elena GeorgeElena George, Anj ReddyAnj Reddy, AJ Nicoll, MC Ryan, Catherine Itsiopoulos, G Abbott, NA Johnson, S Sood, SK Roberts, Audrey TierneyAudrey Tierney
Background: Non-alcoholic fatty liver disease (NAFLD) is predominantly managed by lifestyle intervention, in the absence of effective pharmacotherapies. Mediterranean diet (MedDiet) is the recommended diet, albeit with limited evidence. Aims: To compare an ad libitum MedDiet to low-fat diet (LFD) in patients with NAFLD for reducing intrahepatic lipids (IHL) by proton magnetic resonance spectroscopy (1H-MRS). Secondary outcomes include insulin resistance by homeostatic model of assessment (HOMA-IR), visceral fat by bioelectrical impedance analysis (BIA), liver stiffness measurement (LSM) and other metabolic outcomes. Methods: In this parallel multicentre RCT, subjects were randomised (1:1) to MedDiet or LFD for 12 weeks. Results: Forty-two participants (25 females [60%], mean age 52.3 ± 12.6 years) were included, 23 randomised to LFD and 19 to MedDiet.; 39 completed the study. Following 12 weeks, there were no between-group differences. IHL improved significantly within the LFD group (−17% [log scale]; p =.02) but not within the MedDiet group (−8%, p =.069). HOMA-IR reduced in the LFD group (6.5 ± 5.6 to 5.5 ± 5.5, p <.01) but not in the MedDiet group (4.4 ± 3.2 to 3.9 ± 2.3, p =.07). No differences were found for LSM (MedDiet 7.8 ± 4.0 to 7.6 ± 5.2, p =.429; LFD 11.8 ± 14.3 to 10.8 ± 10.2 p =.99). Visceral fat reduced significantly in both groups; LFD (−76% [log scale], p = <.0005), MedDiet (−61%, p = <.0005). Conclusions: There were no between-group differences for hepatic and metabolic outcomes when comparing MedDiet to LFD. LFD improved IHL and insulin resistance. Significant improvements in visceral fat were seen within both groups. This study highlights provision of dietary interventions in free-living adults with NAFLD is challenging.

Funding

This project was funded by a La Trobe University Research Focus Area `Understanding Disease' grant. This work was supported by an Australian Government Research Training Program Scholarship (ESG, AR). Food was donated for study participant hampers from Boundary Bend, Almond Board of Australia, Jalna, HJ Heinz, Simplot and Carmen's, these companies had no input into the trial design or delivery.

History

Publication Date

2022-06-01

Journal

Liver International

Volume

42

Issue

6

Pagination

15p. (p. 1308-1322)

Publisher

Wiley

ISSN

1478-3223

Rights Statement

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.© 2022 The Authors.