La Trobe
1165349_Nguyen,T_2021.pdf (6.69 MB)

Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients

Download (6.69 MB)
journal contribution
posted on 21.07.2021, 01:07 by THO Nguyen, M Koutsakos, CE van de Sandt, JC Crawford, L Loh, S Sant, L Grzelak, EK Allen, T Brahm, EB Clemens, M Auladell, L Hensen, Z Wang, S Nüssing, X Jia, P Günther, AK Wheatley, S Kent, M Aban, YM Deng, KL Laurie, AC Hurt, Stephanie Gras, J Rossjohn, J Crowe, J Xu, D Jackson, LE Brown, N La Gruta, Weisan Chen, PC Doherty, SJ Turner, TC Kotsimbos, PG Thomas, AC Cheng, K Kedzierska
How innate and adaptive immune responses work in concert to resolve influenza disease is yet to be fully investigated in one single study. Here, we utilize longitudinal samples from patients hospitalized with acute influenza to understand these immune responses. We report the dynamics of 18 important immune parameters, related to clinical, genetic and virological factors, in influenza patients across different severity levels. Influenza disease correlates with increases in IL-6/IL-8/MIP-1α/β cytokines and lower antibody responses. Robust activation of circulating T follicular helper cells correlates with peak antibody-secreting cells and influenza heamaglutinin-specific memory B-cell numbers, which phenotypically differs from vaccination-induced B-cell responses. Numbers of influenza-specific CD8+ or CD4+ T cells increase early in disease and retain an activated phenotype during patient recovery. We report the characterisation of immune cellular networks underlying recovery from influenza infection which are highly relevant to other infectious diseases.

History

Publication Date

11/05/2021

Journal

Nature communications

Volume

12

Issue

1

Article Number

2691

Pagination

(p. 2691)

Publisher

Springer Science and Business Media LLC

ISSN

2041-1723

Rights Statement

The Author reserves all moral rights over the deposited text and must be credited if any re-use occurs. Documents deposited in OPAL are the Open Access versions of outputs published elsewhere. Changes resulting from the publishing process may therefore not be reflected in this document. The final published version may be obtained via the publisher’s DOI. Please note that additional copyright and access restrictions may apply to the published version.

Usage metrics

Journal Articles

Categories

Licence

Exports