Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation

McIntyre, Kim L.; Waters, SA; Zhong, L; Hart-Smith, G; Raftery, M; Chew, ZA; Patel, HR; Graves, Jennifer; D. Waters, Paul

doi:10.26181/26761849.v1

Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation

journal contribution

posted on 2024-08-16, 04:03 authored by Kim L. McIntyre, SA Waters, L Zhong, G Hart-Smith, M Raftery, ZA Chew, HR Patel, Jennifer GravesJennifer Graves, Paul D. Waters

The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica), identifying 135 proteins, of which 54 had orthologues in the XIST interactome. Both interactomes were enriched for biological pathways related to RNA processing, regulation of translation, and epigenetic transcriptional silencing. This represents a remarkable example showcasing the functional coherence of independently evolved lncRNAs in distantly related mammalian lineages.

History

Publication Date

2024-05-23

Journal

Genome Biology

Volume

25

Article Number

134

Pagination

19p.

Publisher

Springer Nature

ISSN

1474-7596

Rights Statement

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