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Haemopedia RNA-seq: A database of gene expression during haematopoiesis in mice and humans

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journal contribution
posted on 09.03.2021, 00:58 by J Choi, TM Baldwin, M Wong, JE Bolden, KA Fairfax, EC Lucas, R Cole, C Biben, C Morgan, KA Ramsay, AP Ng, M Kauppi, LM Corcoran, Wei ShiWei Shi, N Wilson, MJ Wilson, WS Alexander, DJ Hilton, CA De Graaf
© 2018 The Author(s). During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required for oxygen transport, wound healing and immune response. We have updated Haemopedia, a database of gene-expression profiles from a broad spectrum of haematopoietic cells, to include RNA-seq gene-expression data from both mice and humans. The Haemopedia RNA-seq data set covers a wide range of lineages and progenitors, with 57 mouse blood cell types (flow sorted populations from healthy mice) and 12 human blood cell types. This data set has been made accessible for exploration and analysis, to researchers and clinicians with limited bioinformatics experience, on our online portal Haemosphere: https://www.haemosphere. org. Haemosphere also includes nine other publicly available high-quality data sets relevant to haematopoiesis. We have added the ability to compare gene expression across data sets and species by curating data sets with shared lineage designations or to view expression gene vs gene, with all plots available for download by the user.

Funding

National Health and Medical Research Council [Independent Research Institutes Infrastructure Support Scheme, 1113577 to W.S.A., D.J.H, 1058344 to W.S.A., 1048087 to D.J.H., C.M., GNT0637403 to J.E.B., GNT1035229 to C.d.G.]; Australian Cancer Research Foundation; Victorian State Government Operational Infrastructure Support and CSL Limited. Funding for open access charge: The Walter and Eliza Hall Institute.

History

Publication Date

08/01/2019

Journal

Nucleic Acids Research

Volume

47

Issue

D1

Pagination

6p. (p. D780-D785)

Publisher

Oxford University Press

ISSN

0305-1048

Rights Statement

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