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Galectins - important players of the immune response to CNS parasitic infection

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journal contribution
posted on 15.03.2021, 22:56 by Marta Maruszewska-Cheruiyot, Michael Stear, Katarzyna Donskow-Lysoniewska
Galectins are a family of proteins that bind β-galactosides and play key roles in a variety of cellular processes including host defense and entry of parasites into the host cells. They have been well studied in hosts but less so in parasites. As both host and parasite galectins are highly upregulated proteins following infection, galectins are an area of increasing interest and their role in immune modulation has only recently become clear. Correlation of CNS parasitic diseases with mental disorders as a result of direct or indirect interaction has been observed. Therefore, galectins produced by the parasite should be taken into consideration as potential therapeutic agents.

Funding

This work was supported by grant from the National Science Center, Poland no. 2016/23/B/NZ6/03464 and the TEAM TECH/2017-4/22 project carried out within the TEAM TECH programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund.

History

Publication Date

01/05/2021

Journal

Brain, Behavior, and Immunity - Health

Volume

13

Article Number

100221

Pagination

8p. (p. 1-8)

Publisher

Elsevier

ISSN

2666-3546

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